・A Novel Chronic Dural Port Platform for Continuous
・Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology
・Late agingeassociated increases in L-DOPAeinduced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat
・Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
・Central apelin mediates stress-induced gastrointestinal motor dysfunction in rats
・Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
AtmosLM™ Microdialysis with Pressure Canceling Technology
In Vivo Large Molecule Sampling
What is AtmosLM™ Pressure Canceling Technology?
Recovering large molecules, such as cytokines or neuropeptides, by microdialysis has always been challenging due
to large pore size membranes that are required. The membranes will often leak because the pressure inside the
microdialysis probe is comparatively high.
What is AtmosLM™ Pressure Canceling Technology
Atmos LM microdialysis probes have a vent hole in upper part of the probe that prevents the pressure inside the
microdialysis membrane rising above normal atmospheric pressure. The new AtmosLM technology enabled to apply
a large pore membrane to microdialysis probes without allowing leakage. However, the situation with normal
microdialysis probes is quite different because the membrane is part of a closed system. A number of factors
associated with the outlet side of the probe often impact the pressure at the membrane and cause leakage or
variation in the recovery rate.
Sampling Pump (ERP-10)
To remove the microdialysis sample from the probe, a low-pulse sampling pump is
required. This is in addition to the standard syringe pump used for infusion. Eicom
has developed a new peristaltic pump, Model ERP-10, specifically for the
・Two channels on one unit.
・Flow rate as low as 0.5 µL.
・Six rollers per pump head.
Is AtmosLM™ the same as “Push-Pull”?
No, but the new AtmosLM pressure canceling technology is sometimes thought of
as an improved, push-pull technique. The AtmosLM requires significantly shorter
equilibration time before inserting probes because there is no requirement that the
flow rates of the inlet and outlet pumps must be exactly matched. Before the
AtmosLM technique, small mismatches in the pumps led to long equilibrations times
and/or a change in the fluid volume in the brain of the animal.