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Microdialysis
Probe & injection
Reliable.
We have been manufacturing microdialysis probes for over 30 years.
We inspect all probes for functionality before shipping.
Custom made.
Custom size probes are available even for low volume orders.
+ Peptide Microdialysis
+ Brain Microdialysis
+ Brain Microdialysis
+ With Microinjection
+ Flexible Concentric Probe
+ Linear Probe
+ Spinal cord
+ Extra Small Brain
Microinjection
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FX-I-X-Y
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Best for rats or long term experiments.
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Secure attachment to the guide cannula with a threaded cap nut.
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Membrane material: Artificial cellulose with 50,000 Da MWCO.
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Membrane ID/OD: 200/220 µm.
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Available in custom lengths at no additional charge.
Inlet Tubing
Inner 0.04 mm ID PFS*
Outer 0.45 mm OD SUS**
Outlet Tubing
Inner 0.075 mm ID PFS
Outer 0.45 mm OD SUS
Shaft
0.37 mm OD SUS
Artificial Cellulose
Cut Off : MW50,000
ID/OD : 0.2/0.22mm
AC-5
AG-X
AD-X
AC-5 + AD +AG
CX-I-X-Y
journal article
2022
・The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats
2021
・Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity
・Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice
・Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier’s disease, causes behavioral abnormalities
and a hyper-dopaminergic state
・Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal
neuralgia rat model
2020
・G-protein Signaling Regulating Opioid-induced
・Modulation of TASK-1/3 Channels at the Hypoglossal Motoneuron Pool and Effects on Tongue Motor Output and Responses to Excitatory Inputs In-Vivo:
Implications for Strategies for Obstructive Sleep Apnea Pharmacotherapy
・Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma
・Angiopathy with impaired glucose logistics observed in schizophrenia-like model mice
・Brain Angiopathy and Impaired Glucose Metabolism in Model Mice with Psychiatric-Related Phenotypes
2019
・Role of TASK-1/3 Channels at the Hypoglossal Motor Nucleus in Modulating Motor Output
2018
・Hypoxic Preconditioning Maintains GLT-1 Against Transient Global Cerebral Ischemia Through Upregulating Cx43 and Inhibiting c-Src
2017
・Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner
・Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation:
・Analysis using a microdialysis/mass spectrometry integrated system
2016
・Sex Differences in Abuse-Related Neurochemical and Behavioral Effects of 3,4-methylenedioxymethamphetamine (MDMA) in Rats
・Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin
2015
・Glutamate Input in the Dorsal Raphe Nucleus As a Determinant of Escalated Aggression in Male Mice
2013
・Pain-Related Depression of the Mesolimbic Dopamine System in Rats: Expression, Blockade by Analgesics, and Role of Endogenous κ-opioids
CXG-X
CXD-X
・Membrane material: artificial cellulose with a 50,000 Da Molecular Weight Cut Off.
- Other MWCO membranes are available by special order.
・Membrane ID/OD: 200/220 µm.
・Best for mice and short experiments.
CXG-X Guide Cannula
・Shaft: 0.5 mm OD stainless steel.
・The length is designated by X.
・The cup thickness is 2.5 mm.
X is the length of the guide cannula. Available in X = 2, 4, 6, 8, 10, 12 mm.
Y is the length of the membrane. Available in Y = 0.5 to 10 mm, in increments of 0.5 mm.
For faster delivery, consider ordering X = 4, 8, 12 mm and Y = 1, 2, 3 mm.
Other custom lengths may be available.
CX-I-X-Y Probe; 1 each
CXG-X Guide cannule ; 3 pcs/ pk
CXD-X Dummy probes; 3 pcs/ pk
CXSG-X The stereotaxic adaptor of guide; 1 each
MI-FX-X-Y
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Injection cannula (0.075/0.15 mm ID/OD) outside the membrane.
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Position of injection cannula tip specified by the customer. Standard is in the middle of the membrane because it works better to monitor the effect of injection than if positioned at the membrane tip.
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Guide cannula OD is 0.7 mm.
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Refer to the FX probe for X and Y specifications.
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Please specify probe dimensions upon ordering. All probes are tailor-made.
X for shaft length and Y for membrane length. X = 1 to 20 mm, Y = 0.5 to 4 mm
AC-5
MI-AG-X
MI-AD-X
AC-5 +MI- AD +MI-AG
journal article
2015
Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats
2008
Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats
2006
Reduction of methamphetamine‐induced sensitization and reward in matrix metalloproteinase‐2 and ‐9‐deficient mice
2006
Extracellular Ascorbic Acid Radical Formation During Cerebral Ischemia-Reperfusion Utilizing 4-Vessel Occlusion In Rats
2005
Inhibition of Rho-Kinase in the Nucleus Tractus Solitarius Enhances Glutamate Sensitivity in Rats
1998
Effect of Theanine, r-Glutamylethylamide, on Brain Monoamines and Striatal Dopamine Release in Conscious Rats
PEP-X-Y
Variety of Sizes Available for AtmosLM™ Microdialysis Probes
We carry standard sizes of 4, 8, or 12 mm for the shaft length (X mm) and 1, 2, 3, or 4 mm for the membrane length (Y mm). Other sizes are available.
To collect the sample from the probe, a “pull” pump is required in addition to the infusion syringe pump. Eicom has developed a new peristaltic pump, the ERP-10, specifically for the AtmosLM™ system. The ERP-10 completes the AtmosLM™ system offered by Eicom, an incredibly convenient large molecule sampling system.
Membrane material polyethylene. 0.44 mm OD.
Shaft: 0.58 mm OD/0.5 mm ID
journal article
2020
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline
Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning
2019
Late agingeassociated increases in L-DOPAeinduced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat
In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons
Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology
Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large-molecule microdialysis combined with multiplex arrays after acute and chronic ethanol exposure.
2016
Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
2015
Oxidative stress and lipid peroxidation are upstream of amyloid pathology
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist
2014
A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid in the Brain in a Transgenic Model of Alzheimer Disease
Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats
2013
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
TP-X-Y
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Best for blood vessels, GI tract.
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Membrane material: artificial cellulose with a 50,000 Da MWCO.
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Membrane ID/OD: 200/220 µm.
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Flexible shaft is TFE (Teflon®).
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Flexible shaft OD: 0.6 mm.
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Inlet and outlet OD: 0.33 mm (= 26 G needle).
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0.04 mm fused silica tubing inside to minimize dead volume.
Order by specifying probe dimensions. X for TFE tubing length and Y for membrane length.
X = 10 to 200 mm, Y = 1 to 20 mm, TP-100-10 is the most popular size.
journal article
2019
Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis
2012
Development of a novel method for monitoring the antioxidative effect of ascorbic acid in rat blood
2008
Enhancement by Grapefruit Juice of Morphine Antinociception
2008
Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac
2002
In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine4 Receptor in Dog Intestine
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Best for skin and other organs.
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Needle on one end for easy implantation.
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Membrane material: artificial cellulose with a 50,000 Da MWCO.
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Membrane ID/OD: 200/220 µm.
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40 µm diameter platinum wire inside supports membrane.
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Flexible tubing is polyethylene (PE-10).
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Flexible tubing OD: 0.61 mm.
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Inlet and outlet OD: 0.33 mm (= 26 G needle).
Order by specifying probe dimensions. X for each side of PE-10 tubing length and Y for membrane length.
X = 50 to 200 mm, Y = 1 to 20 mm, OP-100-10 is the most popular size.
OP-X-Y
Linear Probe
D-I-X-Y
D-I-X-Y
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Best for direct implantation without guide cannula.
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Smallest and least expensive probe.
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Great for mice.
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Membrane material: artificial cellulose with a 50,000 Da MWCO.
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Membrane ID/OD: 200/220 µm.
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Use probe holder ATH-02 for implant.
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Order by specifying probe dimensions. X for shaft length and Y for membrane length.
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X = 0.5 to 10 mm, Y = 0.5 to 4 mm.
2021
・l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity
in the dorsal striatum, and promotes ambulatory activity in mice
2020
・Simultaneous blood and brain microdialysis in a free-moving mouse to test
blood-brain barrier permeability of chemicals
2019
・Hyperreflexia induced by XLR-11 smoke is caused by the pyrolytic degradant
2017
・Extracellular N-acetylaspartylglutamate released in the nucleus accumbens
modulates the pain sensation:Analysis using a microdialysis/mass spectrometry
integrated system
・Prenatal nicotine exposure decreases the release of dopamine in the medial frontal
cortex and induces atomoxetine-responsive neurobehavioral deficits in mice
2016
・Novel psychoactive benzofurans strongly increase extracellular serotonin level in
mouse corpus striatum
・Brain regions and monoaminergic neurotransmitters that are involved in mouse
ambulatory activity promoted by bupropion
It can be used for spinal cord (injecting drugs or obtaining spinal fluid, etc.)
Please designate the sizes of X, Y, and Z.
The following figure is an example of CU-33-75-10.
CUX-Y-Z
AMI-X
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inlet 0.5 mm (OD)
0.17 mm (ID) x 0.35 mm (OD)
AG-X
AD-X
AC-5
SAG-X
AMI-X (T)
inlet 0.5 mm (OD)
0.06 mm (ID) x 0.15 mm (OD)
AG-X(T)
AD-X(T)
AC-5
SAG-X(T)
2021
・Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice
2020
・α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline
・Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the
Medial Prefrontal Cortex in an Intractable Depression Model
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CXMI-X
Microinjection cannula; 3 pcs/pk
0.17 mm (ID) x 0.35 mm (OD)
CXG-X
Guide Cannula; 3 pcs/pk
CXD-X
Dummy Probes; 3 pcs/pk
CXSG-X
Stereotaxic Adaptor of Guide; 1 each
inlet 0.5 mm (OD)
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CXMI-X (T)
Small microinjection cannula; 3 pcs/pk
0.06 mm (ID) x 0.15 mm (OD)
inlet 0.5 mm (OD)
