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Microdialysis

Probe   &   injection

Reliable.

We have been manufacturing microdialysis probes for over  30  years.

We inspect all probes for functionality before shipping.

Custom made.

Custom size probes are available even for low volume orders.

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+ Peptide Microdialysis

+ Brain Microdialysis

+ Brain Microdialysis

+ With Microinjection

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+ Flexible Concentric Probe

+ Linear Probe

+ Spinal cord

+ Extra Small Brain

Microinjection

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FX-I-X-Y

Eicom-Microdialysis-Probe-Fx-Dimensions.
  • Best for rats or long term experiments.

  • Secure attachment to the guide cannula with a threaded cap nut.

  • Membrane material: Artificial cellulose with 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Available in custom lengths at no additional charge.

Inlet Tubing
Inner 0.04 mm ID PFS*
Outer 0.45 mm OD SUS**

Outlet Tubing
Inner 0.075 mm ID PFS
Outer 0.45 mm OD SUS

Shaft
0.37 mm OD SUS


Artificial Cellulose

Cut Off : MW50,000

ID/OD  : 0.2/0.22mm

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AC-5

AG-X

AD-X

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AC-5 + AD +AG

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CX-I-X-Y

 
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 CXG-X

 CXD-X

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・Membrane material: artificial cellulose with a 50,000 Da Molecular Weight Cut Off.

    - Other MWCO membranes are available by special order.

・Membrane ID/OD: 200/220 µm.

・Best for mice and short experiments.

CXG-X Guide Cannula

・Shaft: 0.5 mm OD stainless steel.

・The length is designated by X.

・The cup thickness is 2.5 mm.

 

X is the length of the guide cannula. Available in X = 2, 4, 6, 8, 10, 12 mm.

Y is the length of the membrane. Available in Y = 0.5 to 10 mm, in increments of 0.5 mm.

For faster delivery, consider ordering X = 4, 8, 12 mm and Y = 1, 2, 3 mm.

Other custom lengths may be available.

CX-I-X-Y  Probe; 1 each

CXG-X     Guide cannule ; 3 pcs/ pk

CXD-X     Dummy probes; 3 pcs/ pk

CXSG-X   The stereotaxic adaptor of guide; 1 each

 
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  • Injection cannula (0.075/0.15 mm ID/OD) outside the membrane.

  • Position of injection cannula tip specified by the customer. Standard is in the middle of the membrane because it works better to monitor the effect of injection than if positioned at the membrane tip.

  • Guide cannula OD is 0.7 mm.

  • Refer to the FX probe for X and Y specifications.

  Please specify probe dimensions upon ordering. All probes are tailor-made.
  X for shaft length and Y for membrane length. X = 1 to 20 mm, Y = 0.5 to 4 mm

MI-FX-X-Y

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AC-5

MI-AG-X

MI-AD-X

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AC-5 +MI- AD +MI-AG

PEP-X-Y

Variety of Sizes Available for AtmosLM™ Microdialysis Probes

We carry standard sizes of 4, 8, or 12 mm for the shaft length (X mm) and 1, 2, 3, or 4 mm for the membrane length (Y mm). Other sizes are available.​

To collect the sample from the probe, a “pull” pump is required in addition to the infusion syringe pump. Eicom has developed a new peristaltic pump, the ERP-10, specifically for the AtmosLM™ system. The ERP-10 completes the AtmosLM™ system offered by Eicom, an incredibly convenient large molecule sampling system. 

Membrane material polyethylene. 0.44 mm OD.
Shaft: 0.58 mm OD/0.5 mm ID

 

​journal article

2020

Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning

2019​

In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons

2019

Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology

2019

Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large-molecule microdialysis combined with multiplex arrays after acute and chronic ethanol exposure.

2016

Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

2015

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

2015

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

2015

Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist

2014

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid  in the Brain in a Transgenic Model of Alzheimer Disease

2014

Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats

2013

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

2013

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

 
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TP-X-Y

  • Best for blood vessels, GI tract.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Flexible shaft is TFE (Teflon®).

  • Flexible shaft OD: 0.6 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

  • 0.04 mm fused silica tubing inside to minimize dead volume.

Order by specifying probe dimensions. X for TFE tubing length and Y for membrane length.
X = 10 to 200 mm, Y = 1 to 20 mm, TP-100-10 is the most popular size.

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  • Best for skin and other organs.

  • Needle on one end for easy implantation.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • 40 µm diameter platinum wire inside supports membrane.

  • Flexible tubing is polyethylene (PE-10).

  • Flexible tubing OD: 0.61 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

 

Order by specifying probe dimensions. X for each side of PE-10 tubing length and Y for membrane length.
X = 50 to 200 mm,  Y = 1 to 20 mm, OP-100-10 is the most popular size.

OP-X-Y

Linear Probe

 

D-I-X-Y

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D-I-X-Y

  • Best for direct implantation without guide cannula.

  • Smallest and least expensive probe.

  • Great for mice.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Use probe holder ATH-02 for implant.

  • Order by specifying probe dimensions. X for shaft length and Y for membrane length.

  • X = 0.5 to 10 mm, Y = 0.5 to 4 mm.

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It can be used for spinal cord (injecting drugs or obtaining spinal fluid, etc.)

Please designate the sizes of X, Y, and Z.

The following figure is an example of CU-33-75-10.

CUX-Y-Z

 

AMI-X 

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inlet 0.5 mm (OD)

0.17 mm (ID) x 0.35 mm (OD)

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AG-X

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AD-X

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AC-5

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SAG-X

AMI-X (T)

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inlet 0.5 mm (OD)

0.06 mm (ID) x 0.15 mm (OD)

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AG-X(T)

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AD-X(T)

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AC-5

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SAG-X(T)

 
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CXMI-X

Microinjection cannula; 3 pcs/pk
0.17 mm (ID) x 0.35 mm (OD)

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CXG-X

Guide Cannula; 3 pcs/pk

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CXD-X

Dummy Probes; 3 pcs/pk

CXSG-X

Stereotaxic Adaptor of Guide; 1 each

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inlet 0.5 mm (OD)

CXMI-X (T) 

Small microinjection cannula; 3 pcs/pk
0.06 mm (ID) x 0.15 mm (OD)

inlet 0.5 mm (OD)

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CXG-X(T)

Small guide cannula; 3 pcs/pk
OD 0.3 mm

CXD-X(T)

Small dummy probe; 3 pcs/pk

CXSG-X(T)

Stereotaxic adapter for implanting small guide ; 1each