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Microdialysis

Probe   &   injection

Reliable.

We have been manufacturing microdialysis probes for over  30  years.

We inspect all probes for functionality before shipping.

Custom made.

Custom size probes are available even for low volume orders.

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+ Peptide Microdialysis

+ Brain Microdialysis

+ Brain Microdialysis

+ With Microinjection

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+ Flexible Concentric Probe

+ Linear Probe

+ Spinal cord

+ Extra Small Brain

Microinjection

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FX-I-X-Y

Eicom-Microdialysis-Probe-Fx-Dimensions.
  • Best for rats or long term experiments.

  • Secure attachment to the guide cannula with a threaded cap nut.

  • Membrane material: Artificial cellulose with 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Available in custom lengths at no additional charge.

Inlet Tubing
Inner 0.04 mm ID PFS*
Outer 0.45 mm OD SUS**

Outlet Tubing
Inner 0.075 mm ID PFS
Outer 0.45 mm OD SUS

Shaft
0.37 mm OD SUS


Artificial Cellulose

Cut Off : MW50,000

ID/OD  : 0.2/0.22mm

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AC-5

AG-X

AD-X

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AC-5 + AD +AG

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CX-I-X-Y

​journal article​​

2022
・The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats
2021
・Characterization and Relative Efficacy of Muscarinic Receptor Antagonism at the Hypoglossal Motor Nucleus to Block Inhibition of Tongue Motor Activity
・Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice
・Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier’s disease, causes behavioral abnormalities
 and a hyper-dopaminergic state

・Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal
 neuralgia rat model

2020
・G-protein Signaling Regulating Opioid-induced
・Modulation of TASK-1/3 Channels at the Hypoglossal Motoneuron Pool and Effects on Tongue Motor Output and Responses to Excitatory Inputs In-Vivo:
  Implications for Strategies for Obstructive Sleep Apnea Pharmacotherapy

・Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma
・Angiopathy with impaired glucose logistics observed in schizophrenia-like model mice
・Brain Angiopathy and Impaired Glucose Metabolism in Model Mice with Psychiatric-Related Phenotypes
2019
・Role of TASK-1/3 Channels at the Hypoglossal Motor Nucleus in Modulating Motor Output
2018
・Hypoxic Preconditioning Maintains GLT-1 Against Transient Global Cerebral Ischemia Through Upregulating Cx43 and Inhibiting c-Src
2017
・Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner
・Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation:
・Analysis using a microdialysis/mass spectrometry integrated system

2016

・Sex Differences in Abuse-Related Neurochemical and Behavioral Effects of 3,4-methylenedioxymethamphetamine (MDMA) in Rats
・Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin
2015
・Glutamate Input in the Dorsal Raphe Nucleus As a Determinant of Escalated Aggression in Male Mice
2013
・Pain-Related Depression of the Mesolimbic Dopamine System in Rats: Expression, Blockade by Analgesics, and Role of Endogenous κ-opioids

 
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 CXG-X

 CXD-X

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・Membrane material: artificial cellulose with a 50,000 Da Molecular Weight Cut Off.

    - Other MWCO membranes are available by special order.

・Membrane ID/OD: 200/220 µm.

・Best for mice and short experiments.

CXG-X Guide Cannula

・Shaft: 0.5 mm OD stainless steel.

・The length is designated by X.

・The cup thickness is 2.5 mm.

 

X is the length of the guide cannula. Available in X = 2, 4, 6, 8, 10, 12 mm.

Y is the length of the membrane. Available in Y = 0.5 to 10 mm, in increments of 0.5 mm.

For faster delivery, consider ordering X = 4, 8, 12 mm and Y = 1, 2, 3 mm.

Other custom lengths may be available.

CX-I-X-Y  Probe; 1 each

CXG-X     Guide cannule ; 3 pcs/ pk

CXD-X     Dummy probes; 3 pcs/ pk

CXSG-X   The stereotaxic adaptor of guide; 1 each

 

MI-FX-X-Y

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  • Injection cannula (0.075/0.15 mm ID/OD) outside the membrane.

  • Position of injection cannula tip specified by the customer. Standard is in the middle of the membrane because it works better to monitor the effect of injection than if positioned at the membrane tip.

  • Guide cannula OD is 0.7 mm.

  • Refer to the FX probe for X and Y specifications.

  Please specify probe dimensions upon ordering. All probes are tailor-made.
  X for shaft length and Y for membrane length. X = 1 to 20 mm, Y = 0.5 to 4 mm

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AC-5

MI-AG-X

MI-AD-X

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AC-5 +MI- AD +MI-AG

PEP-X-Y

Variety of Sizes Available for AtmosLM™ Microdialysis Probes

We carry standard sizes of 4, 8, or 12 mm for the shaft length (X mm) and 1, 2, 3, or 4 mm for the membrane length (Y mm). Other sizes are available.​

To collect the sample from the probe, a “pull” pump is required in addition to the infusion syringe pump. Eicom has developed a new peristaltic pump, the ERP-10, specifically for the AtmosLM™ system. The ERP-10 completes the AtmosLM™ system offered by Eicom, an incredibly convenient large molecule sampling system. 

Membrane material polyethylene. 0.44 mm OD.
Shaft: 0.58 mm OD/0.5 mm ID

​journal article

2020
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques

α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline


Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning


2019​
Late agingeassociated increases in L-DOPAeinduced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat

In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons

Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology

Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large-molecule microdialysis combined with multiplex arrays after acute and chronic ethanol exposure.


2016
Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

2015
Oxidative stress and lipid peroxidation are upstream of amyloid pathology

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist


2014
A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid  in the Brain in a Transgenic Model of Alzheimer Disease

Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats


2013
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

 
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TP-X-Y

  • Best for blood vessels, GI tract.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Flexible shaft is TFE (Teflon®).

  • Flexible shaft OD: 0.6 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

  • 0.04 mm fused silica tubing inside to minimize dead volume.

Order by specifying probe dimensions. X for TFE tubing length and Y for membrane length.
X = 10 to 200 mm, Y = 1 to 20 mm, TP-100-10 is the most popular size.

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  • Best for skin and other organs.

  • Needle on one end for easy implantation.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • 40 µm diameter platinum wire inside supports membrane.

  • Flexible tubing is polyethylene (PE-10).

  • Flexible tubing OD: 0.61 mm.

  • Inlet and outlet OD: 0.33 mm (= 26 G needle).

 

Order by specifying probe dimensions. X for each side of PE-10 tubing length and Y for membrane length.
X = 50 to 200 mm,  Y = 1 to 20 mm, OP-100-10 is the most popular size.

OP-X-Y

Linear Probe

 

D-I-X-Y

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D-I-X-Y

  • Best for direct implantation without guide cannula.

  • Smallest and least expensive probe.

  • Great for mice.

  • Membrane material: artificial cellulose with a 50,000 Da MWCO.

  • Membrane ID/OD: 200/220 µm.

  • Use probe holder ATH-02 for implant.

  • Order by specifying probe dimensions. X for shaft length and Y for membrane length.

  • X = 0.5 to 10 mm, Y = 0.5 to 4 mm.

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It can be used for spinal cord (injecting drugs or obtaining spinal fluid, etc.)

Please designate the sizes of X, Y, and Z.

The following figure is an example of CU-33-75-10.

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CUX-Y-Z

 

AMI-X 

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inlet 0.5 mm (OD)

0.17 mm (ID) x 0.35 mm (OD)

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AG-X

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AD-X

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AC-5

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SAG-X

AMI-X (T)

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inlet 0.5 mm (OD)

0.06 mm (ID) x 0.15 mm (OD)

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AG-X(T)

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AD-X(T)

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AC-5

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SAG-X(T)

 
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CXMI-X

Microinjection cannula; 3 pcs/pk
0.17 mm (ID) x 0.35 mm (OD)

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CXG-X

Guide Cannula; 3 pcs/pk

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CXD-X

Dummy Probes; 3 pcs/pk

CXSG-X

Stereotaxic Adaptor of Guide; 1 each

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inlet 0.5 mm (OD)

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CXMI-X (T) 

Small microinjection cannula; 3 pcs/pk
0.06 mm (ID) x 0.15 mm (OD)

inlet 0.5 mm (OD)

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CXG-X(T)

Small guide cannula; 3 pcs/pk
OD 0.3 mm

CXD-X(T)

Small dummy probe; 3 pcs/pk

CXSG-X(T)

Stereotaxic adapter for implanting small guide ; 1each